Tuesday, August 28, 2007

High Intensity Training is better than Moderate Intensity

Exercise is good for you. But high intensity exercise is best!

This article looks at an experiment that examined the effect of training on tumor necrosis factor (TNF). Those training with the high intensity protocol saw TNF decrease. The implication here is that such training would therefore reduce atherosclerosis (heart disease to you and me). This gets back to the whole idea that high intensity training is more effective for health as I talk about here.

Aerobic exercise attenuates inducible TNF production in humans

Aerobic exercise reduces coronary heart disease risk, but the mechanisms of this protection are not fully understood. Atherosclerosis is an inflammatory disease mediated by monocyte-derived macrophages, which accumulate in arterial plaques and become activated to release factors, including cytokines, that cause damage. Here we studied the effects of aerobic training on monocyte production of tumor necrosis factor (TNF) in whole blood ex vivo. Healthy young sedentary adults (n = 61, age 20–45 yr) were randomized to a moderate- (M) or a high- (H) intensity 12-wk training program. Whole blood was extracted before and after training, and then it was stimulated by addition of lipopolysaccharide (LPS); inducible TNF was measured in the plasma. Data were analyzed according to intention to treat principles using a random-effect model to determine the impact of training group on maximal aerobic capacity and LPS-stimulated TNF after correcting for covariates. Analyses revealed improvement in aerobic capacity in both the H (9%) and the M (7%) groups. However, aerobic training led to significant (P < 0.001) decreases in TNF release only in the H group. These data suggest that in healthy young adults, a 12-wk high-intensity aerobic training program downregulates blood monocyte production of stimulated cytokine release.


high intensity training said...

HIT training has become a favorite among people who wish to loose weight in a short span of time. HIT was earlier practiced only by Bodybuilders and weightlifters as of now athletes who wish to increase their speed and stamina are embracing this technique in a big way.

Pasi said...

Your post dates few years back but because I'm interested in this issue I decided to ask if you have found any explanations for this tolerance for LPS mentioned in this study.

It has been known over two decades that intense excersice increases serum endotoxin (=LPS) concentration. Here are couple examples from pubmed:

Strenuous exercise causes systemic endotoxemia


Exercise-induced endotoxemia: the effect of ascorbic acid supplementation


Have you read/thought about this?