IBD is a a nasty disease so if exercising can help to prevent it, it is a good reason to exercise. Still, speaking to my tame immunologist, people with ulcerative colitis or Crohn's disease are often simply not able to exercise.
Repeated exercise in mice alters expression of IL-10 and TNF-alpha in intestinal lymphocytes.
Hoffman-Goetz L, Spagnuolo PA, Guan J.
Intestinal inflammation is characterized by mucosal damage that may arise, in part, to imbalances in pro- and anti-inflammatory cytokines. The purpose of this study was to describe the effects of repeated bouts of strenuous exercise on cytokine expression in mouse intestinal lymphocytes (IL). Thirty-four female C57BL/6 mice were randomly assigned to three groups: three repeated bouts of treadmill running separated by 24h followed by sacrifice immediately or after a 24h period or a sedentary (no exercise) control. The pro-inflammatory cytokine, TNF-alpha, and the anti-inflammatory cytokine, IL-10, were measured in IL by Western blotting. IL-10 concentration increased by 48% (p<0.05) in the immediate group compared to the sedentary control. TNF-alpha levels in mouse IL were significantly lower 24h after completion of the exercise protocol compared to the immediate group (p<0.05). The results suggest a possible physiological compensation in which intestinal lymphocytes increase the expression of IL-10 in response to exercise-induced stress.