...the pressure of heavy loads carried on the back have the potential to damage the soft tissues of the shoulder, causing microstructural damage to the nerves.
The result could be anything from simple irritation to diminished nerve capacity, ultimately limiting the muscles' ability to respond to the brain's signals, inhibiting movement of the hand and the dexterity of the fingers. In practice, this could impact functionality, reducing a worker's ability to operate machinery, compromise a soldiers' shooting response time, or limiting a child's writing or drawing capacity.The context of the study was soldiers carrying heavy backpacks (I am trying to find the actual study - might be this)
However, it did make me think of the potential damage that could be caused by heavy back squats where you have large weights right on this sensitive area. It also made me think about what Bill DeSimone explained about the squat: