Go Kaleo posted this on Facebook and I thought it was worth sharing further
The full text is at that link
Although it is no longer debatable that sedentary behaviors are an actual cause of many metabolic diseases, the physiology of physical inactivity has been poorly investigated for this purpose. Along with microgravity, the physiological adaptations to spaceflights require metabolic adaptations to physical inactivity, and that is exceedingly well-simulated during the ground-based microgravity bed-rest analogs. Bed rest thus represents a unique model to investigate the mechanisms by which physical inactivity leads to the development of current societal chronic diseases. For decades, however, clinicians and physiologists working in space research have worked separately without taking full awareness of potential strong mutual questioning. This review summarizes the data collected over the last 60 years on metabolic adaptations to bed rest in healthy subjects. Our aim is to provide evidence that supports the hypothesis that physical inactivity per se is one of the primary causes in the development of metabolic inflexibility. This evidence will focus on four main tenants of metabolic inflexiblity: 1) insulin resistance, 2) impaired lipid trafficking and hyperlipidemia, 3) a shift in substrate use toward glucose, and 4) a shift in muscle fiber type and ectopic fat storage. Altogether, this hypothesis places sedentary behaviors upstream on the list of factors involved in metabolic inflexibility, which is considered to be a primary impairment in several metabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus.
It is another one that puts the focus on the dangers of being inactive....sitting around all day....at your desk, in front of the TV, in your car.
Get out and get moving
Stand up!
Comments
Metabolic flexibility as the keystone of health, with a variety of other potential complications downstream when it is lost...
3) a shift in substrate towards glucose
is a "tenant" that could be perhaps be supplied by glucose overfeeding, or constant feeding, in a somewhat more active person; and the two causes could meet halfway...
As one could imagine other causes of these tenants - toxins, for example - affecting the less active members of a population at lower levels than those required to produce metabolic inflexibility in the active.
That more and more I want to quit my job so I don't have to sit all day.
It's like a seed took hold......and now it's growing inside of me and saying.....RUN, GET OUT.....:-)
Find a job where you are not tied down in front of the screen 8 hours a day.
Big cross roads in my life right now.....
Marc
I know what you mean. I took the day off yesterday and went walking in the hills. The weather was awful but I felt so much better at the end of the day. Tired and stimulated. Sitting indoors all day is wrong.