Wednesday, February 11, 2009

Intermittent Fasting - improves survival after heart attacks

Well it seems to help rats.

Intermittent fasting is found to be:

(I hope you are not getting bored by all the IF posts, but these things keep getting published! As ever if you want to learn more you might want to check out Brad Pilon - interviewed here.)

Here is the abstract (edited a bit because blogger was playing up....but you can click on the link to get the whole thing):

Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway

Received 3 September 2008; received in revised form 22 October 2008; accepted 24 October 2008. published online 14 November 2008.

  • Chronic heart failure (CHF) is the major cause of death in the developed countries. Calorie restriction is known to improve the recovery in these patients; however, the exact mechanism behind this protective effect is unknown.
  • Chronic MI was induced in rats by occlusion of the left coronary artery.
  • Two weeks later, the rats were randomly assigned to a normal feeding group (MI-NF) and an alternate-day feeding group (MI-IF).
  • After 6 weeks of observation, we evaluated the effect of intermittent fasting on cellular and ventricular remodeling and long-term survival after CHF.
  • Compared with the normally fed group, intermittent fasting markedly improved the survival of rats with CHF
  • The heart weight body weight ratio was significantly less in the MI-IF group compared to the MI-NF group
  • Isolated heart perfusion studies exhibited well preserved cardiac functions in the MI-IF group compared to the MI-NF group
  • Molecular studies revealed the upregulation of angiogenic factors in the fasted hearts.
  • Immunohistochemical studies confirmed increased capillary density .
  • Moreover fasting also upregulated the expression of other anti-apoptotic factors
  • Chronic intermittent fasting markedly improves the long-term survival after CHF by activation through its pro-angiogenic, anti-apoptotic and anti-remodeling effects.



Brian said...

Never stop posting about IF. It seems to me to be a long-missing link in seeking optimal human health and increased longevity. I love reading about it.

Adam Steer, Better Is Better said...

I "Tweeted" about this one this morning. With the evidence mounting, it's hard to believe anyone can avoid at least taking a serious look at fasting. But the preconceived notions about it are pretty firmly entrenched.

However, a pretty mainstream nutrition guy did a couple blog posts about IF this week, which I though was very cool.