Sunday, September 12, 2010

Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy.

This is an interesting study.  The context is clinical, treating people with conditions that lead to muscle wasting.  Anyway rather than just try to feed these patients up, they are realising that they need resistance exercise in order to promote growth and put the food to use.

Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy.

PURPOSE OF REVIEW: Loss of skeletal muscle mass is a common feature of a number of clinical scenarios including limb casting, bed rest, and various disorders such as HIV-AIDS, sepsis, cancer cachexia, heart failure, and uremia. Commonly, muscle disuse (hypodynamia) is the sole reason, or a large part, of why muscle mass is lost. The reduction in strength, or dynapenia, that accompanies these conditions is also a function of the degree of hypodynamia and is related to muscle loss.

RECENT FINDINGS: The major and consistent finding in a number of human-based models of muscle wasting is a decline in the synthesis of new muscle proteins both in the postabsorptive and fed states. Thus, countermeasures are best suited to those that augment muscle protein synthesis and not those that attempt to counteract proteolysis. Our main thesis is that retention of muscle mass in wasting conditions will be achieved to the greatest extent by focussing on increased muscle use with moderate-to-high resistance loads as the primary countermeasure with a secondary countermeasure being to provide adequate nutritional support. Either intervention alone will alleviate some part of hypodynamia-induced muscle mass loss and dynapenia; however, together nutrition and muscular contraction will result in greater mitigation of muscle loss.

SUMMARY: Advances in our understanding of hypodynamia-induced muscle loss, a condition common to almost all syndromes of muscle wasting, has led to a focus on reduced basal and feeding-induced elevations in protein synthesis. Countermeasures for wasting should focus on stimulating anabolism rather than alleviating catabolism.


Chuck said...

did the study say specifically what the "adequate nutrition" was? i can assume quality and quantity of protein in the diet but i am curious what was discussed in this study.

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Nice article..very informative..Running is more effective than regular exercise for weight loss.

Unknown said...

Exercise is wonderful general workout for body. It very effective in building chest, triceps, shoulders and core muscles. There bench that you lie down on and then there either bar or dumb bells that are for you to push away from your body. Breathe out as you push weights away and breathe in as you release bar closer to chest.

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