Intermittent Fasting Research

We haven't had any new IF Research for a while.

Here is a quick podcast for you to listen to:

Fasting May Equal Calorie-Restricted Diets

A study in the journal Nature finds that worms that fasted every third day got the same anti-aging benefits offered by severe calorie-restricted diets.

The report is referring to this study:

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Dietary restriction is the most effective and reproducible intervention to extend lifespan in divergent species1. In mammals, two regimens of dietary restriction, intermittent fasting (IF) and chronic caloric restriction, have proven to extend lifespan and reduce the incidence of age-related disorders2. An important characteristic of IF is that it can increase lifespan even when there is little or no overall decrease in calorie intake2. The molecular mechanisms underlying IF-induced longevity, however, remain largely unknown. Here we establish an IF regimen that effectively extends the lifespan of Caenorhabditis elegans, and show that the low molecular weight GTPase RHEB-1 has a dual role in lifespan regulation; RHEB-1 is required for the IF-induced longevity, whereas inhibition of RHEB-1 mimics the caloric-restriction effects. RHEB-1 exerts its effects in part by the insulin/insulin growth factor (IGF)-like signalling effector DAF-16 in IF. Our analyses demonstrate that most fasting-induced upregulated genes require RHEB-1 function for their induction, and that RHEB-1 and TOR signalling are required for the fasting-induced downregulation of an insulin-like peptide, INS-7. These findings identify the essential role of signalling by RHEB-1 in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway.

Dry January

I mentioned a few weeks ago that I was taking part in "Dry January". I didn't make a big song and dance about it, but I decided to go for a calendar month or so with no alcohol. A few people have asked me about my experience, so here are a few points. Why take a break from drinking? Alcohol is an interesting topic. As a drug it is widely accepted in society, central to so much of our socialising and leisure. There seem to be lots of health benefits - so we are told - yet there are also a lot of problems in terms of health, relationships and lifestyle that come from drinking. Over a few years I'd begun to become aware and then concerned that I was drinking too much and too regularly. I am in a busy and stressful job and sometimes a glass of wine after work to relax is really helpful. But over time, one glass became two. Two glasses became ....I might as well finish the bottle. A habit got established....and was starting to get too e...

So where have I been?

You will have noticed that this blog has been quiet for a while.... There are a few reasons for that, reasons that I thought I'd list here: WORK - my day job has been incredibly busy and stressful this year. Working 10-14 hour days the last thing on my mind when I got home was putting something on here. FACEBOOK/TWITTER - I suppose I've been using other channels to do some of what I used to do here. Quick fire posts pointing to interesting studies or news etc tend to get posted to Twitter (@chrishighcock) or to the Facebook Hillfit group http://www.facebook.com/groups/263083947097000/ REASSESSMENT - I've found myself less comfortable with some of the positions I've taken in the past. Sometimes I'm embarrassed by some of the things I've promoted. I'm not Paleo or low carb. I think Tabata and intervals are misunderstood and misapplied. I cannot really claim to be HIT. I find myselfunable honestly to post things on here and pretend that I am some sort o...

Taking up space for a brief update

I've a couple of posts in draft that I will get up soon - an update / reflection on Dry January and some thoughts on the scheduling benefits of short workouts if your life is busy. Before that though, I am pointing to something else. However, I wanted to highlight something that is coming this weekend that I've been involved in. Amber Rogers (Gokaleo and author of Taking Up Space ) has been pulling together a bundle of books from various authors with a common theme, one that I've been pushing here recently. Keep it simple, avoid the hype, be patient, be consistent and flee the gurus. I've talked before about how we get obsessed with pushing for more and more, when enough is OK. I've given my view that so much of the health and fitness internet world is more like a gnostic religion than something that will benefit your life. There are other voices out there saying similar things and I'll be pointing to a bundle of books later this week ...

Conditioning Research

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