Skip to main content

Chronic Cardio is healthy?

In our little paleosphere endurance exercise is usually characterised as a "bad" thing.  Mark Sission's Chronic Cardio post is the usual basis for all this, but there are other references too.  In general I agree with this view.  However sometimes other bits and pieces pop up that indicate a different viewpoint.  I saw this one the other day:

Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

The purpose of this study was to evaluate whether ultra endurance exercise changes the mRNA levels of the autophagy-related and autophagy-regulatory genes. Eight men (44 ± 1 years, range: 38–50 years) took part in a 200-km running race. The average running time was 28 h 03 min ± 2 h 01 min (range: 22 h 15 min–35 h 04 min). A muscle sample was taken from the vastus lateralis 2 weeks prior to the race and 3 h after arrival. Gene expression was assessed by RT-qPCR. Transcript levels of autophagy-related genes were increased by 49% for ATG4b (P = 0.025), 57% for ATG12 (P = 0.013), 286% for Gabarapl1 (P = 0.008) and 103% for LC3b (P = 0.011). The lysosomal enzyme cathepsin L mRNA was upregulated by 123% (P = 0.003). Similarly, transcript levels of the autophagy-regulatory genes BNIP3 and BNIP3l were both increased by 113% (P = 0.031 and P = 0.007, respectively). Since upregulation of these genes has been related with an increased autophagic flux in various models, our results strongly suggest that autophagy is activated in response to ultra endurance exercise.

Autophagy is usually presented as a "good thing" - the self eating process by which cells clean themselves up, getting rid of waste products and some pathogens.  Often it is promoted by fasting and again in the paleo world it is one of the benefits that are claimed for intermittent fasting.  I've probably written about that in the past somewhere.

Anyway, this study seems to link it to ultraendurance exercise.....actually it is talking epigenetics as far as I can see, particular autophagy related genes being switched on.  I suppose this might make sense if the exercise has actually cause massive damage and the body is frantically trying to clear up and repair the mess.  Maybe not so positive.
Labels:

Comments

sustenir said…
Cleaning up some unwanted proteins is fine, but I assume muscle wasting would look the same under this lens. It's well-known that the increase in stress hormones during the race would put you into a more catabolic state and encourage muscle breakdown. Cleaning up after significant muscular damage is probably also a factor, as you say.
December 31, 2011 at 10:20 AM
Post a Comment

Popular posts from this blog

Dry January

I mentioned a few weeks ago that I was taking part in "Dry January".  I didn't make a big song and dance about it, but I decided to go for a calendar month or so with no alcohol.  A few people have asked me about my experience, so here are a few points. Why take a break from drinking? Alcohol is an interesting topic.  As a drug it is widely accepted in society, central to so much of our socialising and leisure.  There seem to be lots of health benefits - so we are told - yet there are also a lot of problems in terms of health, relationships and lifestyle that come from drinking. Over a few years I'd begun to become aware and then concerned that I was drinking too much and too regularly.  I am in a busy and stressful job and sometimes a glass of wine after work to relax is really helpful.  But over time, one glass became two.  Two glasses became ....I might as well finish the bottle.  A habit got established....and was starting to get too e...
7 comments
Read more

So where have I been?

You will have noticed that this blog has been quiet for a while....  There are a few reasons for that, reasons that I thought I'd list here: WORK -  my day job has been incredibly busy and stressful this year. Working 10-14 hour days the last thing on my mind when I got home was putting something on here.  FACEBOOK/TWITTER - I suppose I've been using other channels to do some of what I used to do here. Quick fire posts pointing to interesting studies or news etc tend to get posted to Twitter (@chrishighcock) or to the Facebook Hillfit group http://www.facebook.com/groups/263083947097000/  REASSESSMENT - I've found myself less comfortable with some of the positions I've taken in the past. Sometimes I'm embarrassed by some of the things I've promoted. I'm not Paleo or low carb. I think Tabata and intervals are misunderstood and misapplied. I cannot really claim to be HIT.   I find myselfunable  honestly to post things on here and pretend that I am some sort o...
12 comments
Read more

Taking up space for a brief update

I've a couple of posts in draft that I will get up soon -  an update / reflection on Dry January and some thoughts on the scheduling benefits of short workouts if your life is busy.  Before that though, I am pointing to something else. However, I wanted to highlight something that is coming this weekend that I've been involved in.   Amber Rogers (Gokaleo and author of Taking Up Space ) has been pulling together a bundle of books from various authors with a common theme, one that I've been pushing here recently.   Keep it simple, avoid the hype, be patient, be consistent and flee the gurus.   I've talked before about how we get obsessed with pushing for more and more, when enough is OK.  I've given my view that so much of the health and fitness internet world is more like a gnostic religion than something that will benefit your life. There are other voices out there saying similar things and I'll be pointing to a bundle of books later this week ...
1 comment
Read more